CYD-2-11 |CAS:1425944-22-4 Probechem Biochemicals

Chemical Structure : CYD-2-11

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CYD-2-11

货号: PC-60924Not For Human Use, Lab Use Only.

CYD-2-11 is a novel potent, selective Bax agonist that targets the structural pocket proximal to S184 in the C-terminal region of Bax (Ki=34.1 nM).

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生物&药学活性

CYD-2-11 is a novel potent, selective Bax agonist that targets the structural pocket proximal to S184 in the C-terminal region of Bax (Ki=34.1 nM).
CYD-2-11 shows no affinity for other Bcl-2 family members.
CYD-2-11 directly activates Bax proapoptotic activity by inducing a conformational change enabling formation of Bax homooligomers in mitochondrial membranes.
CYD-2-11 suppresses malignant growth without evident significant toxicity to normal tissues in mutant KRAS-driven lung cancer models.
CYD-2-11 displays strong synergistic activity and overcomes rapalog resistance combined with RAD001.

物理化学性质&存储条件

分子量	358.397
分子式	C22H18N2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-2-(2-((2-nitro-9H-fluoren-9-ylidene)methyl)phenoxy)ethan-1-amine

参考文献

1. Li R, et al. Cancer Res. 2017 Jun 1;77(11):3001-3012.

CYD-2-11

生物&药学活性

物理化学性质&存储条件

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CYD-2-11

生物&药学活性

物理化学性质&存储条件

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