Fadraciclib (CYC065) | CDK2/9 inhibitor | Probechem Biochemicals

Chemical Structure : CYC065

CAS No.: 1070790-89-4

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CYC065 (Fadraciclib, CYC-065)

货号: PC-61248Not For Human Use, Lab Use Only.

CYC065 (Fadraciclib) is a derivative of seliciclib and second generation CDK inhibitor with IC50 of 5/26 nM for CDK2/9.

规格	价格	库存
5 mg	￥1580	In stock
10 mg	￥2280	In stock
25 mg	￥3680	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

CYC065 (Fadraciclib) is a derivative of seliciclib and second generation CDK inhibitor with IC50 of 5/26 nM for CDK2/9.
CYC065 demonstrates cytotoxicity both in MM cell lines sensitive as well as resistant to conventional chemotherapy with IC50 of 0.06-2 uM.
CYC065 blocks cells in the G1 phase and inhibits cell growth specifically in CCNE1-overexpressing USCs.
CYC065 significantly reduces tumour growth in xenografts derived from CCNE1-amplified USCs.
CYC065 shows synergistic effect in vitro and in vivo combined with Taselisib.

物理化学性质&存储条件

分子量	397.527
分子式	C21H31N7O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: 100 mg/mL
Chemical Name/SMILES	(2R,3S)-3-[[6-[(4,6-dimethylpyridin-3-yl)methylamino]-9-propan-2-ylpurin-2-yl]amino]pentan-2-ol

参考文献

1. Cocco E, et al. Br J Cancer. 2016 Jul 26;115(3):303-11.

2. Kawakami M, et al. J Natl Cancer Inst. 2017 Jun 1;109(6).

3. Thomas AL, et al. Cell Cycle. 2017 Aug 3;16(15):1453-1464.

4. Rao SS, et al. Oncotarget. 2017 Aug 10;8(48):83925-83939.

CYC065 (Fadraciclib, CYC-065)

生物&药学活性

物理化学性质&存储条件

参考文献

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CYC065 (Fadraciclib, CYC-065)

生物&药学活性

物理化学性质&存储条件

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