CXL017 | SERCA inhibitor | Probechem Biochemicals

Chemical Structure : CXL017

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CXL017 (CXL-017)

货号: PC-62866Not For Human Use, Lab Use Only.

CXL017 is a small molecule that has selective cytotoxicity toward MDR cancer cell lines in vitro, through inhibition of the sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA) with IC50 of 15 uM.

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生物&药学活性

CXL017 is a small molecule that has selective cytotoxicity toward MDR cancer cell lines in vitro, through inhibition of the sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA) with IC50 of 15 uM.
CXL017 selectively suppresses the growth of tumors derived from the MDR cancer cell line, HL60/MX2, in vivo.
CXL017 significantly downregulates Mcl-1 and Bax and up-regulates Noxa, Bim, Bcl-XL, SERCA2, and SERCA3 proteins, along with a reduction in endoplasmic reticulum (ER) calcium content in HL60/MX2 cells.
CXL017 elicits its cytotoxic effect, in part, through inhibition of the SERCA.

物理化学性质&存储条件

分子量	441.48
分子式	C24H27NO7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Ethyl 2-amino-6-(3,5-dimethoxyphenyl)-4-(2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate

参考文献

1. Das SG, et al. ACS Chem Biol. 2013 Feb 15;8(2):327-35.

2. Aridoss G, et al. J Med Chem. 2012 Jun 14;55(11):5566-81.

3. Hermanson DL, et al. Mol Pharmacol. 2013 Aug;84(2):236-43.

4. Bleeker NP, et al. Mol Pharm. 2013 Nov 4;10(11):4358-66.

CXL017 (CXL-017)

生物&药学活性

物理化学性质&存储条件

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CXL017 (CXL-017)

生物&药学活性

物理化学性质&存储条件

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