Zabadinostat (CXD101) | class I HDAC inhibitor | Probechem Biochemicals

Chemical Structure : CXD101

CAS No.: 934828-12-3

加入收藏

CXD101 (Zabadinostat, CXD-101)

货号: PC-42249Not For Human Use, Lab Use Only.

Zabadinostat (CXD101) is a potent, selective and orally active class I HDAC inhibitor with IC50s of 63 nM, 570 nM and 550 nM for HDAC1, HDAC2 and HDAC3, respectively, has no activity against class II HDACs.

规格	价格	库存
5 mg	￥1280	In stock
10 mg	￥1980	In stock
25 mg	￥3280	In stock
50 mg	￥5280	In stock
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

Zabadinostat (CXD101) is a potent, selective and orally active class I HDAC inhibitor with IC50s of 63 nM, 570 nM and 550 nM for HDAC1, HDAC2 and HDAC3, respectively, has no activity against class II HDACs.

Zabadinostat (CXD101) shows IC50 of 0.2-15 uM against colon, lung, non-Hodgkin lymphoma, and myeloma cell lines.

Zabadinostat (CXD101) treatment increased expression of MHC class I and II genes in a variety of cells, including dendritic cells (DCs) and healthy tissue.

物理化学性质&存储条件

分子量	403.52
分子式	C24H29N5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 31 mg/mL
Chemical Name/SMILES	Benzamide, N-(2-aminophenyl)-4-[1-[(1,3-dimethyl-1H-pyrazol-4-yl)methyl]-4-piperidinyl]-

参考文献

1. PCT Int. Appl. (2007), WO 2007045844 A1 20070426.
2. Geng Liu, et al. Commun Biol. 2023 Jan 26;6(1):102.
3. Eyre TA, et al. Cancer. 2019 Jan 1;125(1):99-108.

CXD101 (Zabadinostat, CXD-101)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

CXD101 (Zabadinostat, CXD-101)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.