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首页-小分子抑制剂&激动剂-GPCR-Chemokine Receptor (CCR and CXCR)-CXCR7 agonist 1
CXCR7 agonist 1

Chemical Structure : CXCR7 agonist 1

CAS No.: 937265-89-9

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CXCR7 agonist 1

货号: PC-38669Not For Human Use, Lab Use Only.

CXCR agonist 1 is a potent, selective, small molecule agonist of CXCR7 (ACKR3), induces β-arrestin recruitment to CXCR7 and Akt activation, inhibits CXCL12-induced tube formation in HUVECs with EC50 of 0.96 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    CXCR7 agonist 1 is a potent, selective, small molecule agonist of CXCR7 (ACKR3), induces β-arrestin recruitment to CXCR7 and Akt activation, inhibits CXCL12-induced tube formation in HUVECs with EC50 of 0.96 nM.

    物理化学性质&存储条件

    分子量 447.332
    分子式 C24H19BrN2O2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1-((6-bromopyridin-2-yl)methyl)-3-(3,4-dimethylbenzoyl)quinolin-4(1H)-one

    参考文献

    1. Ayako Uto-Konomi, et al. Biochem Biophys Res Commun. 2013 Feb 22;431(4):772-6.

    2. Adlere I, et al. Mol Pharmacol. 2019 Dec;96(6):737-752.

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