CXCR6 inhibitor 81 |CAS:2579689-85-1 Probechem Biochemicals

Chemical Structure : CXCR6 inhibitor 81

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CXCR6 inhibitor 81

货号: PC-38129Not For Human Use, Lab Use Only.

CXCR6 inhibitor 81 is a potent (EC50=40 nM) and selective orally bioavailable small molecule antagonist of human CXCR6 receptor.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

CXCR6 inhibitor 81 is a potent (EC50=40 nM) and selective orally bioavailable small molecule antagonist of human CXCR6 receptor.
Compound 81 displays >10-fold improvement in potency in both the β-arrestin and cAMP assays (IC50 =40 and 540 nM, respectively) compared to ML339.
CXCR6 inhibitor 81 inhibits migration of SK-HEP-1 hepatoma cells in a dose dependent manner.
Compound 81 has promising oral DMPK data, significantly decreases tumor growth in a 30-day mouse xenograft model of HCC.

物理化学性质&存储条件

分子量	549.609
分子式	C27H30F3N3O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 1 Month
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3,4,5-trimethoxy-N-((1R,3s,5S)-9-((4-(trifluoromethyl)benzo[d]thiazol-2-yl)methyl)-9-azabicyclo[3.3.1]nonan3-yl)benzamide

参考文献

1. Satyamaheshwar Peddibhotla, et al. Bioorg Med Chem Lett. 2020 Feb 15;30(4):126899.