CXCR3 antagonist 7D

Chemical Structure : CXCR3 antagonist 7D

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货号: PC-23096Not For Human Use, Lab Use Only.

CXCR3 antagonist 7D is a specific small molecule CXCR3 antagonist, inhibits CXCL4-mediated DENV2 replication with EC50 of 2.1 uM in monocytic U937-DC-SIGN cells.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

CXCR3 antagonist 7D is a specific small molecule CXCR3 antagonist, inhibits CXCL4-mediated DENV2 replication with EC50 of 2.1 uM in monocytic U937-DC-SIGN cells.
7D (5μM) suppressed the CXCL4-mediated enhancement of DENV2 replication, similar to the effect of AMG487.
7D inhibits the replication of all other serotypes DENV1, DENV3 and DENV4 in vitro.
7D increased IFN synthesis via CXCR3 axis in vitro.
7D improves dengue disease pathology and mice survivability alongside increases IFN synthesis, enhances DENV2-specific antibodies in infected mice.

物理化学性质&存储条件

分子量	536.63
分子式	C32H32N4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1-cyclohexyl-2-(4-methoxyphenyl)-1H-benzo[d]imidazole-5-carbonyl)-L-tryptophan

参考文献

1. Gaur KK, et al. EMBO Mol Med. 2024 Sep 16. doi: 10.1038/s44321-024-00137-8.