CXCR2 inhibitor 68 | CXCR2 antagonist | Probechem Biochemicals

Chemical Structure : CXCR2 inhibitor 68

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CXCR2 inhibitor 68 (CXCR2-IN-2)

货号: PC-62775Not For Human Use, Lab Use Only.

CXCR2-IN-68 is a potent, selective, brain penetrant, and orally bioavailable CXCR2 antagonist with pIC50 of 9.0, displays 730-fold selectivity over CXCR1 and >1,900-fold selectivity over all other chemokine receptors.

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生物&药学活性

CXCR2 inhibitor 68 is a potent, selective, brain penetrant, and orally bioavailable CXCR2 antagonist with pIC50 of 9.0, displays 730-fold selectivity over CXCR1 and >1,900-fold selectivity over all other chemokine receptors.
CXCR2 inhibitor 68 inhibits human whole blood Gro-α induced CD11b expression with IC50 of 0.04 µM, 17-fold more potent than Navarixin.
CXCR2 inhibitor 68 significantly inhibits neutrophil infiltration in mouse at 1, 3, 10 mg/kg oral dosing twice daily (BID).

物理化学性质&存储条件

分子量	414.901
分子式	C18H23ClN2O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(4-chloro-2-hydroxy-3-(((S)-3-methyltetrahydrofuran-3-yl)sulfonyl)phenyl)-3-((R)-2-methylcyclopent-2-en-1-yl)urea

参考文献

1. Lu H, et al. J Med Chem. 2018 Feb 28. doi: 10.1021/acs.jmedchem.7b01854.

CXCR2 inhibitor 68 (CXCR2-IN-2)

生物&药学活性

物理化学性质&存储条件

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CXCR2 inhibitor 68 (CXCR2-IN-2)

生物&药学活性

物理化学性质&存储条件

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