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首页-小分子抑制剂&激动剂-GPCR-Chemokine Receptor (CCR and CXCR)-CX797
CX797

Chemical Structure : CX797

CAS No.: 1611496-70-8

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CX797 (CX-797, CX 797)

货号: PC-60626Not For Human Use, Lab Use Only.

CX797 is a potent, specfic CXCR2 antagonist that inhibits IL8 down-regulation of forskolin-induced cAMP with IC50 of 7.79 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    CX797 is a potent, specfic CXCR2 antagonist that inhibits IL8 down-regulation of forskolin-induced cAMP with IC50 of 7.79 uM.
    CX797 inhibits IL8-mediated cAMP signaling and receptor degradation while specifically up-regulating IL8-mediated β-arrestin-2 recruitment.
    CX797 also inhibits IL8-mediated cell migration.

    物理化学性质&存储条件

    分子量 382.5
    分子式 C19H18N4OS2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (R)-6-methyl-1-(methylthio)-4-phenyl-6,7,8,9-tetrahydrobenzo[4,5]thieno[3,2-e][1,2,4]triazolo[4,3-a]pyrimidin-5(4H)-one

    参考文献

    1. Ha H, et al. Mol Pharm. 2014 Jul 7;11(7):2431-41.

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