CX-6258 | Pim inhibitor | Probechem Biochemicals

Chemical Structure : CX-6258

CAS No.: 1202916-90-2

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CX-6258 (CX6258, CX 6258)

货号: PC-45415Not For Human Use, Lab Use Only.

CX-6258 (CX6258) is a potent, selective, and orally efficacious pan-Pim inhibitor with IC50 of 5/25/16 nM for Pim1/2/3, respectively.

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10 mg	￥980	In stock
25 mg	￥1580	In stock
50 mg	￥2580	In stock
100 mg		Get quote

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生物&药学活性

CX-6258 (CX6258) is a potent, selective, and orally efficacious pan-Pim inhibitor with IC50 of 5/25/16 nM for Pim1/2/3, respectively.
CX-6258 exhibits in vitro synergy with chemotherapeutics and robust in vivo efficacy in driven tumor models.
CX-6258 also decreases steady state levels and half-life of NKX3.1 protein but not mRNA in prostate cancer cells.

物理化学性质&存储条件

分子量	461.9401
分子式	C26H24ClN3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2H-Indol-2-one, 5-chloro-3-[[5-[3-[(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)carbonyl]phenyl]-2-furanyl]methylene]-1,3-dihydro-, (3E)-

参考文献

1. Haddach M, et al. ACS Med Chem Lett. 2011 Dec 27;3(2):135-9.

2. Padmanabhan A, et al. J Cell Biochem. 2013 May;114(5):1050-7.

3. Rebello RJ, et al. Clin Cancer Res. 2016 Nov 15;22(22):5539-5552.

CX-6258 (CX6258, CX 6258)

生物&药学活性

物理化学性质&存储条件

参考文献

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CX-6258 (CX6258, CX 6258)

生物&药学活性

物理化学性质&存储条件

参考文献

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