CX-3543 | RNA Pol I inhibitor | Probechem Biochemicals

Chemical Structure : CX-3543

CAS No.: 865311-47-3

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CX-3543 (Quarfloxin, Itarnafloxin, CX3543)

货号: PC-62219Not For Human Use, Lab Use Only.

CX-3543 (Quarfloxin, Itarnafloxin) is a small molecule nucleolus-targeting agent that selectively disrupts nucleolin/rDNA G-quadruplex complexes in the nucleolus, thereby inhibiting RNA Pol I transcription and inducing apoptosis in cancer cells.

规格	价格	库存
5 mg	￥1980	In stock
10 mg	￥2980	In stock
25 mg	￥4880	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

CX-3543 (Quarfloxin, Itarnafloxin) is a small molecule nucleolus-targeting agent that selectively disrupts nucleolin/rDNA G-quadruplex complexes in the nucleolus, thereby inhibiting RNA Pol I transcription and inducing apoptosis in cancer cells.

物理化学性质&存储条件

分子量	604.67
分子式	C35H33FN6O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-fluoro-N-(2-((S)-1-methylpyrrolidin-2-yl)ethyl)-3-oxo-6-((R)-3-(pyrazin-2-yl)pyrrolidin-1-yl)-3H-benzo[b]pyrido[3,2,1-kl]phenoxazine-2-carboxamide

参考文献

1. Drygin D, et al. Cancer Res. 2009 Oct 1;69(19):7653-61.

2. Stokes JM, et al. Nat Chem Biol. 2015 Dec;11(12):924-32.

3. Xu H, et al. Nat Commun. 2017 Feb 17;8:14432.

CX-3543 (Quarfloxin, Itarnafloxin, CX3543)

生物&药学活性

物理化学性质&存储条件

参考文献

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CX-3543 (Quarfloxin, Itarnafloxin, CX3543)

生物&药学活性

物理化学性质&存储条件

参考文献

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