CWI1-2 | IGF2BP2 inhibitor | Probechem Biochemicals

Chemical Structure : CWI1-2

CAS No.: 2408590-36-1

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CWI1-2 (IGF2BP2 inhibitor)

货号: PC-49558Not For Human Use, Lab Use Only.

CWI1-2 is a small molecule inhibitor of m6A reader IGF2BP2, shows promising anti-leukemia effects in vitro and in vivo.

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10 mg	￥1880	In stock
25 mg	￥3280	In stock
50 mg	￥5280	In stock
100 mg		Get quote

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生物&药学活性

CWI1-2 is a small molecule inhibitor of m6A reader IGF2BP2, shows promising anti-leukemia effects in vitro and in vivo.
IGF2BP2 promotes AML development and self-renewal of leukemia stem/initiation cells by regulating expression of critical targets (e.g., MYC, GPT2, and SLC1A5) in the glutamine metabolism pathways in an m6A-dependent manner.
High expression of IGF2BP2 is observed in AML and associates with unfavorable prognosis.

物理化学性质&存储条件

分子量	519.77
分子式	C22H17Cl3N6O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-N',N''-bis((E)-5-chloro-2-hydroxybenzylidene)-2-((Z)-5-chloro-2-hydroxybenzylidene)hydrazine-1-carbohydrazonhydrazide

参考文献

1. Weng H, et al. Cancer Cell. 2022 Dec 12;40(12):1566-1582.e10.

CWI1-2 (IGF2BP2 inhibitor)

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物理化学性质&存储条件

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CWI1-2 (IGF2BP2 inhibitor)

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