CVT-10216 |CAS:1005334-57-5 Probechem Biochemicals

Chemical Structure : CVT-10216

CAS No.: 1005334-57-5

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CVT-10216 (CVT 10216;GS455534;GS-455534)

货号: PC-61349Not For Human Use, Lab Use Only.

CVT-10216 (CVT10216) is a potent, highly selective, reversible inhibitor of ALDH2 with IC50 of 29 nM, shows no significant inhibition for ALDH1 (IC50=1,300 nM).

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5 mg	￥1480	In stock
10 mg	￥2280	In stock
25 mg	￥3980	In stock
50 mg	￥5980	In stock
100 mg		Get quote

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生物&药学活性

CVT-10216 (CVT10216) is a potent, highly selective, reversible inhibitor of ALDH2 with IC50 of 29 nM, shows no significant inhibition for ALDH1 (IC50=1,300 nM).
CVT-10216 demonstrates therapeutic potential to reduce excessive drinking and to suppress relapse in abstinent alcoholics.
CVT-10216 also shows both anxiolytic and antidipsotropic properties in rats.
CVT-10216 selectively suppresses binge eating of palatable food and attenuates dopamine release in the accumbens of sugar-bingeing rats.

物理化学性质&存储条件

分子量	465.5
分子式	C24H19NO7S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-[[[3-[4-[(Methylsulfonyl)amino]phenyl]-4-oxo-4H-1-benzopyran-7-yl]oxy]methyl]benzoic acid

参考文献

1. Arolfo MP, et al. Alcohol Clin Exp Res. 2009 Nov;33(11):1935-44.

2. Overstreet DH, et al. Pharmacol Biochem Behav. 2009 Dec;94(2):255-61.

3. Bocarsly ME, et al. Behav Pharmacol. 2014 Apr;25(2):147-57.

CVT-10216 (CVT 10216;GS455534;GS-455534)

生物&药学活性

物理化学性质&存储条件

参考文献

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CVT-10216 (CVT 10216;GS455534;GS-455534)

生物&药学活性

物理化学性质&存储条件

参考文献

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