欢迎访问ProbeChem中文网站,英文网站请访问www.probechem.com

首页-小分子抑制剂&激动剂-Others-Other Targets-CVN424
CVN424

Chemical Structure : CVN424

CAS No.: 2254706-21-1

CVN424 (CVN-424, CVN 424)

货号: PC-72762Not For Human Use, Lab Use Only.

CVN424 (CVN 424) is a highly potent, selective, brain-penetrant, orally active GPR6 inverse agonist with EC50 of 38 nM.

规格 价格 库存 数量
5 mg ¥2480 In stock
10 mg ¥3980 In stock
25 mg ¥5980 In stock
50 mg Get quote
100 mg Get quote

大包装,大折扣!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

CVN424 (CVN 424) is a highly potent, selective, brain-penetrant, orally active GPR6 inverse agonist with EC50 of 38 nM.
Oral administration of CVN424 dose-dependently increases locomotor activity and reverses haloperidol-induced catalepsy.
CVN424 restored mobility in bilateral 6-hydroxydopamine lesion model of Parkinson disease.
CVN424 is brain-penetrant and shows dose-dependent receptor occupancy that attained brain 50% of receptor occupancy at plasma concentrations of 6.0 and 7.4 ng/ml in mice and rats, respectively.
CVN424 is effective in preclinical models and is a potential therapeutic for improving motor function in patients with Parkinson disease.

物理化学性质&存储条件

分子量 473.525
分子式 C24H29F2N5O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(R)-1-(2-(4-(2,4-difluorophenoxy)piperidin-1-yl)-3-((tetrahydrofuran-3-yl)amino)-7,8-dihydropyrido[3,4-b]pyrazin-6(5H)-yl)ethan-1-one

参考文献

1. Brice NL, et al. J Pharmacol Exp Ther. 2021 Jun;377(3):407-416.

2. M, Green J, et al. J Med Chem. 2021 Jul 22;64(14):9875-9890.

3. Margolin DH, et al. J Pharmacol Exp Ther. 2022 Feb 2:JPET-AR-2021-000842. 

备案号:沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: