CVN293 | THIK-1 inhibitor | Probechem Biochemicals

Chemical Structure : CVN293

加入收藏

CVN293 (CVN-293)

货号: PC-22344Not For Human Use, Lab Use Only.

CVN293 (CVN-293) is a potent, selective and brain permeable potassium (K+) ion channel KCNK13 (THIK-1, K2P13.1) inhibitor with IC50 of 41 nM and 28 nM for human and mouse KCNK13, respectively.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

CVN293 (CVN-293) is a potent, selective and brain permeable potassium (K+) ion channel KCNK13 (THIK-1, K2P13.1) inhibitor with IC50 of 41 nM and 28 nM for human and mouse KCNK13, respectively.
CVN293 demonstrates minimal inhibition for most closely related channels KCNK2 and KCNK6 at 10 uM.
CVN293 blocked the release of IL-1β from microglia in a concentration-dependent manner, with a potency of 24 nM.
CVN293 (1 uM) attenuated the LPS/ATP-induced release of IL-1β in mouse cultured hippocampal slices.
CVN293 potently inhibits the NLRP3-inflammasome mediated production of the proinflammatory cytokine IL-1β in microglia.

物理化学性质&存储条件

分子量	311.28
分子式	C14H10FN7O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-[7-Fluoro-1-(3-pyridazinylmethyl)-1H-benzimidazol-2-yl]-1,2,5-oxadiazol-3-amine

参考文献

1. Bürli RW, et al. ACS Med Chem Lett. 2024 Apr 5;15(5):646-652.

CVN293 (CVN-293)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

CVN293 (CVN-293)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.