CVM-6-139-1 | HIPK2 inhibitor | Probechem Biochemicals

Chemical Structure : CVM-6-139-1

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CVM-6-139-1 (HIPK2 inhibitor A64)

货号: PC-73291Not For Human Use, Lab Use Only.

CVM-6-139-1 (HIPK2 inhibitor A64) is a potent small molecule HIPK2 kinase inhibitor, blocks HIPK2 phosphorylation on S359/T360 and JNK activation in HEK293 cells and attenuates ER stress-induced cell death with EC50 of 401 nM.

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100 mg		Get quote

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生物&药学活性

CVM-6-139-1 (HIPK2 inhibitor A64) is a potent small molecule HIPK2 kinase inhibitor, blocks HIPK2 phosphorylation on S359/T360 and JNK activation in HEK293 cells and attenuates ER stress-induced cell death with EC50 of 401 nM.
CVM-6-139-1 blocks p-HIPK2 [S359/T360] in primary spinal motor neurons and protected >60% of these neurons from tunicamycin- and SOD1G93A-induced cell death.
CVM-6-139-1 attenuates TDP-43 proteinopathy-induced cell death in HEK293 cells and spinal motor neurons.
CVM-6-139-1 protects neurons from cell death induced by either wild type or mutant TDP-43.

物理化学性质&存储条件

分子量	383.426
分子式	C18H17N5O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2,4-Thiazolidinedione, 5-[[1,2-dihydro-2-oxo-6′-(1-piperazinyl)[3,3′-bipyridin]-5-yl]methylene]-

参考文献

1. Sebum Lee, et al. Neuron. 2016, 91(1), 41-55.

2. Miduturu CV et al. Chem Biol. 2011;18:868–879.

CVM-6-139-1 (HIPK2 inhibitor A64)

生物&药学活性

物理化学性质&存储条件

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CVM-6-139-1 (HIPK2 inhibitor A64)

生物&药学活性

物理化学性质&存储条件

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