CUR61414 | Hh signaling inhibitor, Smoothened inhibitor

Chemical Structure : CUR61414

CAS No.: 334998-36-6

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CUR61414 (G856, CUR-61414)

货号: PC-62178Not For Human Use, Lab Use Only.

CUR61414 is a small molecule Hedgehog (Hh) inhibitor that can block elevated Hh signaling activity resulting from oncogenic mutations in Patched-1, binds directly with Smoothened (Ki=44 nM).

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5 mg	￥980	In stock
10 mg	￥1580	In stock
25 mg	￥2780	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

CUR61414 is a small molecule Hedgehog (Hh) inhibitor that can block elevated Hh signaling activity resulting from oncogenic mutations in Patched-1, binds directly with Smoothened (Ki=44 nM).
CUR61414 inhibits Hh-induced cellular activity (IC50=100-200 nM).
CUR61414 suppresses proliferation and induces apoptosis of basaloid nests in the BCC model systems, whereas having no effect on normal skin cells.

物理化学性质&存储条件

分子量	550.7
分子式	C31H42N4O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[(3S,5S)-1-(1,3-benzodioxol-5-ylmethyl)-5-(1-piperazinylcarbonyl)-3-pyrrolidinyl]-N-[(3-methoxyphenyl)methyl]-3,3-dimethyl-butanamide

参考文献

1. Williams JA, et al. Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4616-21.

2. Angot E, et al. Stem Cells. 2008 Sep;26(9):2311-20.

3. Frank-Kamenetsky M, et al. J Biol. 2002 Nov 6;1(2):10.

CUR61414 (G856, CUR-61414)

生物&药学活性

物理化学性质&存储条件

参考文献

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CUR61414 (G856, CUR-61414)

生物&药学活性

物理化学性质&存储条件

参考文献

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