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首页-小分子抑制剂&激动剂-Others-Other Targets-CU239
CU239

Chemical Structure : CU239

CAS No.: 946249-82-7

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CU239 (CU 239, CU-239)

货号: PC-63457Not For Human Use, Lab Use Only.

CU239 is a novel non-retinoid RPE65 inhibitor that selectively inhibits isomerase activity of RPE65 with IC50 of 6 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    CU239 is a novel non-retinoid RPE65 inhibitor that selectively inhibits isomerase activity of RPE65 with IC50 of 6 uM.
    CU239 inhibits RPE65 via competition with its substrate all-trans-retinyl ester.
    CU239 suppresses visual cycle and prevents retinal degeneration in mice.

    物理化学性质&存储条件

    分子量 436.409
    分子式 C19H15F3N4O3S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-(2-(3-phenylureido)thiazol-4-yl)-N-(4-(trifluoromethoxy)phenyl)acetamide

    参考文献

    1. Shin Y, et al. Biochim Biophys Acta. 2018 Apr 21. pii: S0925-4439(18)30146-7.

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