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首页-小分子抑制剂&激动剂-Immunology/Inflammation-Toll-like Receptor (TLR)-CU-CPT22
CU-CPT22

Chemical Structure : CU-CPT22

CAS No.: 1416324-85-0

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CU-CPT22 (CU-CPT 22)

货号: PC-38135Not For Human Use, Lab Use Only.

CU-CPT22 is a specific small-molecule inhibitor of the TLR1/TLR2 complex with IC50 of 0.58 uM (NO production in RAW 264.7 cells).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

CU-CPT22 is a specific small-molecule inhibitor of the TLR1/TLR2 complex with IC50 of 0.58 uM (NO production in RAW 264.7 cells).
CU-CPT22 preferentially inhibits TLR2/1 signaling, without affecting a panel of homologous TLRs (TLR2/6, TLR3, TLR4, and TLR7).
CU-CPT22 competes with the synthetic triacylated lipoprotein (Pam3CSK4) binding to TLR1/2 with high inhibitory activity and specificity.
CU-CPT22 demonstrated minimal non-specific inhibition against a panel of 10 representative kinases (PDGFRB, MET, DDR2, SRC, MAPK1, PAK1, AKT1, PKC-γ, CAMK1, and PLK4).
CU-CPT22 also inhibits the downstream signaling transduction in cellular assays, inhibits TNF-α (60%) and IL-1β (95%) at 8 uM in the Pam3CSK4-activated RAW 264.7 cells.
CU-CPT22 reduced the nuclear translocation of NF-κB and secretion of TNF-α from cultured primary mouse microglia.
CU-CPT22 also inhibits the downstream signaling transduction in cellular assays, inhibits TNF-α (60%) and IL-1β (95%) at 8 uM in the Pam3CSK4-activated RAW 264.7 cells.

物理化学性质&存储条件

分子量 362.378
分子式 C19H22O7
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 1 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Hexyl 3,4,6-trihydroxy-2-methoxy-5-oxo-5H-benzo[7]annulene-8-carboxylate

参考文献

1. Cheng K, et al. Angew Chem Int Ed Engl. 2012 Dec 3;51(49):12246-9.

2. Daniele SG, et al. Sci Signal. 2015 May 12;8(376):ra45.

3. Bock S, et al. Pharmacol Res. 2016 Mar;105:44-53.

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