CU-CPD107 | TLR8 agonist | Probechem Biochemicals

Chemical Structure : CU-CPD107

CAS No.: 2573912-32-8

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CU-CPD107 (TLR8 agonist)

货号: PC-72053Not For Human Use, Lab Use Only.

CU-CPD107 is a TLR8-specific small molecule with unique synergistic agonist activities in the presence of ssRNA, but inactive without the aid of ssRNA.

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生物&药学活性

CU-CPD107 is a TLR8-specific small molecule with unique synergistic agonist activities in the presence of ssRNA, but inactive without the aid of ssRNA.
CU-CPD107 significantly inhibited of R848-induced signaling in HEK-Blue hTLR8 cells with an IC50 of 13.7 uM.
CU-CPD107 only inhibited synthesized small-molecule agonist-induced TLR8 signaling without affecting other TLRs.
CU-CPD107 synergistically increased IFN-β, TNF-α, IL-1β, IL-6, and IL-8 mRNA expression levels in the presence of 5 μg/ml ssRNA40 in HEK-Blue hTLR8 cells, whereas CU-CPD107 alone did not. CU-CPD107 only activated TLR8-mediated signaling in the presence of ssRNA.
CU-CPD107 showed no pure agonistic activity, addressing a major challenge that has existed for previous TLR7 and TLR8 agonists as vaccine adjuvants or antiviral drugs.

物理化学性质&存储条件

分子量	400.26
分子式	C16H21IN2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(2-(ethoxymethyl)-4-iodo-5-phenyl-1H-imidazol-1-yl)-2-methylpropan-2-ol

参考文献

1. Yi Yang, et al. Nat Commun. 2021 Jul 16;12(1):4351.

CU-CPD107 (TLR8 agonist)

生物&药学活性

物理化学性质&存储条件

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CU-CPD107 (TLR8 agonist)

生物&药学活性

物理化学性质&存储条件

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