CTPS-IN-T35 | CTPS inhibitor | Probechem Biochemicals

Chemical Structure : CTPS-IN-T35

CAS No.: 2338811-71-3

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CTPS-IN-T35 (STP-C, CTPS inhibitor T35)

货号: PC-72551Not For Human Use, Lab Use Only.

CTPS-IN-T35 is a potent, small molecule inhibitor of CTPS (cytidine triphosphate synthase) with IC50 of 4.7/25.7 nM against CTPS1/2 in RapdFire MS assays.

规格	价格	库存
5 mg	￥1480	In stock
10 mg	￥2280	In stock
25 mg	￥3880	In stock
50 mg	￥5980	In stock
100 mg		Get quote

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生物&药学活性

CTPS-IN-T35 is a potent, small molecule inhibitor of CTPS (cytidine triphosphate synthase) with IC50 of 4.7/25.7 nM against CTPS1/2 in RapdFire MS assays.
CTPS-IN-T35 inhibited lymphocyte proliferation (Jurkat cells IC50=6 nM, human/mouse T-Cells IC50=24/63.5 nM) by preventing expansion of CTP pools via de novo synthesis.

物理化学性质&存储条件

分子量	512.526
分子式	C20H19F3N6O3S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(2-(cyclopropanesulfonamido)thiazol-4-yl)-2-methyl-N-(5-(6-(trifluoromethyl)pyrazin-2-yl)pyridin-2-yl)propanamide

参考文献

1. Eric M Lynch, et al. Proc Natl Acad Sci U S A. 2021 Oct 5;118(40):e2107968118.

CTPS-IN-T35 (STP-C, CTPS inhibitor T35)

生物&药学活性

物理化学性质&存储条件

参考文献

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CTPS-IN-T35 (STP-C, CTPS inhibitor T35)

生物&药学活性

物理化学性质&存储条件

参考文献

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