CTN06 | BMX/BTK inhibitor | Probechem Biochemicals

Chemical Structure : CTN06

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CTN06 (BMX/BTK inhibitor CTN06)

货号: PC-35180Not For Human Use, Lab Use Only.

CTN06 is a potent Etk (BMX) and Btk dual inhibitor with IC50 of 200 and 50 nM, respectively.

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生物&药学活性

CTN06 is a potent Etk (BMX) and Btk dual inhibitor with IC50 of 200 and 50 nM, respectively.
CTN06 weakly inhibits Itk (IC50=0.5 uM), and shows no inhibition on Src (IC50=5 uM) and Mer (IC50=10 uM).
CTN06 effectively kills PC3 and other prostate cancer cells, induces autophagy as well as apoptosis in prostate cancer cells.
CTN06 inhibits the phosphorylation of Btk, Etk and the downstream signal PLCγ2, Stat3, Akt in prostate cancer cells.
CTN06 inhibits PC3 xenograft tumor growth in vivo.

物理化学性质&存储条件

分子量	563.706
分子式	C33H37N7O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(7-isobutyl-6-oxo-1-(3-(piperidin-1-yl)propyl)-5,6-dihydro-1H-imidazo[4,5-g]quinoxalin-2-yl)-4-(pyridin-4-yl)benzamide

参考文献

1. Guo W, et al. Cell Death Dis. 2014 Sep 4;5:e1409.

CTN06 (BMX/BTK inhibitor CTN06)

生物&药学活性

物理化学性质&存储条件

参考文献

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CTN06 (BMX/BTK inhibitor CTN06)

生物&药学活性

物理化学性质&存储条件

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