CTLA-4 inhibitor D11.3

Chemical Structure : CTLA-4 inhibitor D11.3

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货号: PC-21772Not For Human Use, Lab Use Only.

CTLA-4 inhibitor D11.3 is a small molecule inhibitor of cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) with IC50 of 0.97 uM in AlphaLISA assays.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
200 mg		Get quote
1 g		Get quote

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生物&药学活性

CTLA-4 inhibitor D11.3 is a small molecule inhibitor of cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) with IC50 of 0.97 uM in AlphaLISA assays.
CTLA-4 inhibitor D11.3 (5 mg/kg or 12.5 mg/kg) markedly reduced tumor growth without affecting the body weight in in established syngeneic mouse models expressing transgenic humanized CTLA-4 protein.

物理化学性质&存储条件

分子量	346.86
分子式	C22H19ClN2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-benzyl-3-(4-chlorophenyl)-4-phenyl-4,5-dihydro-1H-pyrazole

参考文献

1. Navid Sobhani, et al. BJC Rep. 2024:2:4. doi: 10.1038/s44276-023-00035-5.