CTLA-4 inhibitor A9.1

Chemical Structure : CTLA-4 inhibitor A9.1

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货号: PC-21773Not For Human Use, Lab Use Only.

CTLA-4 inhibitor A9.1 is a small molecule inhibitor of cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) with IC50 of 1.4 uM in AlphaLISA assays.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
200 mg		Get quote
1 g		Get quote

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生物&药学活性

CTLA-4 inhibitor A9.1 is a small molecule inhibitor of cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) with IC50 of 1.4 uM in AlphaLISA assays.
CTLA-4 inhibitor A9.1 (5 mg/kg or 12.5 mg/kg) markedly reduced tumor growth without affecting the body weight in in established syngeneic mouse models expressing transgenic humanized CTLA-4 protein.

物理化学性质&存储条件

分子量	380.42
分子式	C21H21FN4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-N-(3-fluoro-4-methylphenyl)-2-(((1-(5-methyl-2-phenyl-1H-imidazol-4-yl)ethylidene)amino)oxy)acetamide

参考文献

1. Navid Sobhani, et al. BJC Rep. 2024:2:4. doi: 10.1038/s44276-023-00035-5.