CTIBD | BKCa activator | Probechem Biochemicals

Chemical Structure : CTIBD

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CTIBD (BKCa channel activator)

货号: PC-72121Not For Human Use, Lab Use Only.

CTIBD is a novel potent activator of the BKCa channel with EC50 of 3.9 uM.

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生物&药学活性

CTIBD is a novel potent activator of the BKCa channel with EC50 of 3.9 uM.
CTIBD showed significantly higher potency compared with three other known BKCa activators: NS 1619, NS 11021, and rottlerin.
CTIBD induced a reversible potentiation of macroscopic outward currents of the BKCa channel, CTIBD activates both rSlo/rβ1 and rSlo/rβ4 coexpressed channels mainly by decreasing the closing rate of the channel.
CTIBD concentration-dependently reduced ACh-induced contractions in isolated rat urinary bladder strips.
CTIBD effectively restored frequent voiding contraction and lowered voiding volume without affecting other bladder function parameters in acetic acid-induced overactive bladder (OAB) model (i.p. 20 mg/kg).

物理化学性质&存储条件

分子量	355.697
分子式	C16H9ClF3NO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(4-(4-chlorophenyl)-3-(trifluoromethyl)isoxazol-5-yl)benzene-1,3-diol

参考文献

1. Narasaem Lee, et al. Mol Pharmacol. 2021 Feb;99(2):114-124.

CTIBD (BKCa channel activator)

生物&药学活性

物理化学性质&存储条件

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CTIBD (BKCa channel activator)

生物&药学活性

物理化学性质&存储条件

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