CTDP-32476 | DAT inhibitor | Probechem Biochemicals

Chemical Structure : CTDP-32476

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CTDP-32476 (CTDP32476)

货号: PC-35476Not For Human Use, Lab Use Only.

CTDP-32476 is a potent and selective dopamine transporter (DAT) inhibitor and a competitive inhibitor of cocaine binding to the DAT with Ki of 12 nM.

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生物&药学活性

CTDP-32476 is a potent and selective dopamine transporter (DAT) inhibitor and a competitive inhibitor of cocaine binding to the DAT with Ki of 12 nM.
CTDP-32476 demonstrates 20-fold higher affinity for the DAT than cocaine.
CTDP-32476 is more potent than methylphenidate in blocking [3H]-cocaine binding.
Systemic administration of CTDP-32476 alone produced a slow-onset, long-lasting increase in extracellular nucleus accumbens DA, locomotion, and brain-stimulation reward, inhibited cocaine self-administration, cocaine-associated cue-induced relapse to drug seeking, and cocaine-enhanced extracellular DA in the nucleus accumbens.

物理化学性质&存储条件

分子量	302.283
分子式	C16H25Cl2N
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-2-((R)-1-(4-chlorophenyl)-3-methylbutyl)piperidine hydrochloride

参考文献

1. Xi ZX, et al. Neuropsychopharmacology. 2017 Feb;42(3):682-694.

CTDP-32476 (CTDP32476)

生物&药学活性

物理化学性质&存储条件

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CTDP-32476 (CTDP32476)

生物&药学活性

物理化学性质&存储条件

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