CTA056 | ITK inhibitor | Probechem Biochemicals

Chemical Structure : CTA056

CAS No.: 1265822-30-7

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CTA056 (CTA 056, CTA-056)

货号: PC-35182Not For Human Use, Lab Use Only.

CTA056 (CTA 056) is a potent, selective inhibitor of interleukin-2-inducible T-cell kinase (ITK) with IC50 of ~100 nM, also inhibits Btk (IC50=400 nM), but shows no significant inhibition for Etk (BMX kinase, IC50=5 uM).

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10 mg	￥7280	In stock
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生物&药学活性

CTA056 (CTA 056) is a potent, selective inhibitor of interleukin-2-inducible T-cell kinase (ITK) with IC50 of ~100 nM, also inhibits Btk (IC50=400 nM), but shows no significant inhibition for Etk (BMX kinase, IC50=5 uM).
CTA056 shows selectivity for Itk over other Tec family members; inhibits the phosphorylation of Itk and its effectors including PLC-γ, Akt, and ERK, as well as the decreased secretion of targeted genes such as IL-2 and IFN-γ in treated Jurkat and MOLT-4 cells.
CTA056 also exhibits apoptosis-inducing potential in Jurkat cells.
CTA056 demonstrates cytotoxic effect in xenograft models of T-cell leukemia and lymphoma.

物理化学性质&存储条件

分子量	554.698
分子式	C35H34N6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7-benzyl-1-(3-(piperidin-1-yl)propyl)-2-(4-(pyridin-4-yl)phenyl)-1H-imidazo[4,5-g]quinoxalin-6(5H)-one

参考文献

1. Guo W, et al. Mol Pharmacol. 2012 Nov;82(5):938-47.

CTA056 (CTA 056, CTA-056)

生物&药学活性

物理化学性质&存储条件

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CTA056 (CTA 056, CTA-056)

生物&药学活性

物理化学性质&存储条件

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