Baleraciclideg (CT7439, CT-7439) | CDK12/13 inhibitor, Cyclin K degrader

Chemical Structure : CT7439

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CT7439 (CT-7439, Baleraciclideg)

货号: PC-27409Not For Human Use, Lab Use Only.

CT7439 (CT-7439) is a potent, selective and oral cyclin-dependent kinases CDK12/CDK13 inhibitor and monovalent glue degrader of cyclin K (CCNK), inhibites OV-90 cell growth with IC50 of 4.4 nM.

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生物&药学活性

Baleraciclideg (CT7439, CT-7439) is a potent, selective and oral cyclin-dependent kinases CDK12/CDK13 inhibitor and monovalent glue degrader of cyclin K (CCNK), inhibites OV-90 cell growth with IC50 of 4.4 nM.
CT7439 inhibits DDR genes (BRCA1, ERCC4, RAD51C and POLQ).
CT7439 exhibits a strong combination activity between CT7439 and the PARP inhibitors Olaparib, Niraparib and AZD10530 as well as the carboplatin in OV-90 cellular confluency assay.

物理化学性质&存储条件

分子量	439.57
分子式	C26H29N7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-3-cyclopropyl-N5-(piperidin-3-yl)-N7-(4-(pyridin-2-yl)benzyl)pyrazolo[1,5-a]pyrimidine-5,7-diamine

参考文献

1. Watlington WK, et al. Mol Oncol. 2026 Jun 30:10.1002/1878-0261.70290.

2. Patent WO2022263604 A1 2022-12-22.

3. Ashwani K. Bahl, et al. Cancer Res (2025) 85 (8_Supplement_1): 7004.

CT7439 (CT-7439, Baleraciclideg)

生物&药学活性

物理化学性质&存储条件

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CT7439 (CT-7439, Baleraciclideg)

生物&药学活性

物理化学性质&存储条件

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