欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-Others-Other Targets-CT-179
CT-179

Chemical Structure : CT-179

CAS No.: 1996636-69-1

加入收藏

CT-179 (CT179)

货号: PC-38755Not For Human Use, Lab Use Only.

CT-179 is a small molecule inhibitor of protein transcription factor OLIG2 (Oligodendrocyte transcription factor 2), CT-179 is a putative disruptor of OLIG2 homodimerization.

规格 价格 库存 数量
2 mg ￥1980 In stock
5 mg ￥2980 In stock
10 mg ￥4680 In stock
25 mg Get quote
100 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: 99.5% (HPLC) Select Batch:

生物&药学活性

CT-179 is a small molecule inhibitor of protein transcription factor OLIG2 (Oligodendrocyte transcription factor 2), CT-179 is a putative disruptor of OLIG2 homodimerization.
CT-179 profoundly inhibited the growth of, and induced apoptosis in, a range of patient-derived HGG cell lines at low nanomolar concentrations.
CT-179 caused significant downregulation of receptor tyrosine kinases that are associated with HGG tumorigenicity, including EGFR and PDGFR. Orally administered CT-179 (20 mg/kg) crossed the blood-brain barrier of intact mice and reached levels sufficient to inhibit HGG cells.
CT-179 inhibited cell viability of pediatric glioblastoma (pGBM) cells in vitro, and effectively penetrated and accumulated in CNS tissues and PDOX tumors.

物理化学性质&存储条件

分子量 397.304
分子式 C17H22Cl2N6O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-(2-(3-(3,4-Dichlorophenyl)ureido)-6-methyl-pyrimidin-4-yl)-amino-3(dimethylamino)propane

参考文献

1. Xu Z, et al. Clin Cancer Res. 2022 May 26:clincanres.0527.2022-3-18 13:13:01.167.

2. Holly Lindsay, et al. Cancer Res (2019) 79 (13_Supplement): LB-320.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: