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首页-小分子抑制剂&激动剂-Others-Other Targets-CSRM617 hydrochloride
CSRM617 hydrochloride

Chemical Structure : CSRM617 hydrochloride

CAS No.: 1353749-74-2

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CSRM617 hydrochloride (CSRM-617)

货号: PC-35956Not For Human Use, Lab Use Only.

CSRM617 hydrochloride (CSRM-617) is a small-molecule inhibitor of the transcription factor ONECUT2 (OC2) with Kd of 7.43 uM in SPR assays, binds to OC2-HOX domain directly.

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10 mg ￥1280 In stock
25 mg ￥1980 In stock
50 mg ￥2980 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

CSRM617 hydrochloride (CSRM-617) is a small-molecule inhibitor of the transcription factor ONECUT2 (OC2) with Kd of 7.43 uM in SPR assays, binds to OC2-HOX domain directly.
CSRM617 inhibits cell growth and induced apoptosis in vitro in several PC cell lines that expressed moderate to high levels of OC2.
CSRM617 significantly downregulates PEG10 protein levels in tumors from mice, suppresseses metastasis in 22Rv1 cells implanted subcutaneously nude mice.

物理化学性质&存储条件

分子量 291.688
分子式 C10H14ClN3O5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(E)-2-amino-3-hydroxy-N'-(2,3,4-trihydroxybenzylidene)propanehydrazide hydrochloride

参考文献

1. Rotinen M, et al. Nat Med. 2018 Dec;24(12):1887-1898.

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