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CSRM617

Chemical Structure : CSRM617

CAS No.: 787504-88-5

CSRM617 (CSRM-617, CSRM 617)

货号: PC-35864Not For Human Use, Lab Use Only.

CSRM617 (CSRM-617) is a small-molecule inhibitor of the transcription factor ONECUT2 (OC2) with Kd of 7.43 uM in SPR assays, binds to OC2-HOX domain directly.

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生物&药学活性

CSRM617 (CSRM-617) is a small-molecule inhibitor of the transcription factor ONECUT2 (OC2) with Kd of 7.43 uM in SPR assays, binds to OC2-HOX domain directly,
CSRM617 inhibits cell growth and induced apoptosis in vitro in several PC cell lines that expressed moderate to high levels of OC2,
CSRM617 significantly downregulates PEG10 protein levels in tumors from mice treated with CSRM617, suppresseses metastasis in 22Rv1 cells implanted subcutaneously nude mice.

物理化学性质&存储条件

分子量 255.23
分子式 C10H13N3O5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-amino-3-hydroxy-N'-(2,3,4-trihydroxybenzylidene)propanehydrazide

参考文献

1. Rotinen M, et al. Nat Med. 2018 Nov 26. doi: 10.1038/s41591-018-0241-1.

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