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首页-新冠病毒相关-SARS-CoV-2 Inhibitors-CSNK2A inhibitor 2
CSNK2A inhibitor 2

Chemical Structure : CSNK2A inhibitor 2

CAS No.: 2470424-33-8

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CSNK2A inhibitor 2 (CK2 inhibitor Compound 2)

货号: PC-72808Not For Human Use, Lab Use Only.

CSNK2A inhibitor 2 (CK2 inhibitor Compound 2) is a potent, selective, cell active ATP-competitive inhibitor of host protein kinase Casein Kinase 2 (CSNK2A1/2, pIC50=8.5-8.6), inhibits the pathogenic β-coronaviruses including SARS-CoV-2 (MHV pIC50=8.6)

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    CSNK2A inhibitor 2 (CK2 inhibitor Compound 2) is a potent, selective, cell active ATP-competitive inhibitor of host protein kinase Casein Kinase 2 (CSNK2A1/2, pIC50=8.5-8.6), inhibits the pathogenic β-coronaviruses including SARS-CoV-2 (MHV pIC50=8.6).
    Treatment of the HEK293T-ACE2 cells with 1 μM of the CSNK2A chemical probe SGC-CK2-1 or CSNK2A inhibitor 2 resulted in a 70–80% decrease in spike protein uptake.
    Chemical probe CSNK2A inhibitor 2 showed inhibition of virus replication at nanomolar doses where it has remarkably high kinase selectivity.
    CSNK2A inhibitor 2 inhibits MHV-nLuc replication in DBT cells with IC50 of <10 nM.

    物理化学性质&存储条件

    分子量 433.52
    分子式 C22H27N9O
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(5-((3-cyano-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidin-5-yl)amino)-2-(methyl(2-(methylamino)ethyl)amino)phenyl)acetamide

    参考文献

    1. Carrow I Wells, et al. Cell Chem Biol. 2021 Apr 15;28(4):546-558.e10.

    2. Xuan Yang, et al. bioRxiv. 2022 Jan 4;2022.01.03.474779.

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