CSLP43 | RIPK2 inhibitor | Probechem Biochemicals

Chemical Structure : CSLP43

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CSLP43 (RIPK2 inhibitor CSLP43)

货号: PC-35429Not For Human Use, Lab Use Only.

CSLP43 (RIPK2 inhibitor CSLP43) is a novel potent, ATP pocket-binding RIPK2 inhibitor with IC50 of 19.9 nM in ADPGlo assay, demonstrates inhibition of both the RIPK2-XIAP interaction, and of cellular and in vivo NOD2 signaling.

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生物&药学活性

CSLP43 (RIPK2 inhibitor CSLP43) is a novel potent, ATP pocket-binding RIPK2 inhibitor with IC50 of 19.9 nM in ADPGlo assay, demonstrates inhibition of both the RIPK2-XIAP interaction, and of cellular and in vivo NOD2 signaling.
CSLP43 exhibits inhibition of TNF release from RAW264.7 cells with EC50 of 1.2 nM, inhibits NF-κB reporter activity with IC50 of 1.34 nM.
CSLP43 antagonizes NOD2 signaling by interfering with the XIAP-RIPK2 interaction, selectively inhibits NOD responses in cells (HEKBlue NOD2 IC50=1.3 nM) and displays potent activity in vivo, does not attenuates the TNF release following an unrelated pro-inflammatory stimulation mediated through TLR4 activation by LPS at 1 uM.

物理化学性质&存储条件

分子量	511.641
分子式	C26H33N5O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(5-(2-amino-5-(4-(piperazin-1-yl)phenyl)pyridin-3-yl)-2,3-dimethoxyphenyl)propane-1-sulfonamide

参考文献

1. Hrdinka M, et al. EMBO J. 2018 Jul 19. pii: e99372.

CSLP43 (RIPK2 inhibitor CSLP43)

生物&药学活性

物理化学性质&存储条件

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CSLP43 (RIPK2 inhibitor CSLP43)

生物&药学活性

物理化学性质&存储条件

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