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首页-小分子抑制剂&激动剂-Tyrosine Kinase-Src-CSK inhibitor 13
CSK inhibitor 13

Chemical Structure : CSK inhibitor 13

CAS No.: 2380027-49-4

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CSK inhibitor 13 (SI-3, SRC inhibitor 3)

货号: PC-25884Not For Human Use, Lab Use Only.

CSK inhibitor 13 (SI-3, CSK-IN-1) is a potent, selective inhibitor of C-terminal Src kinase (CSK) with IC50 of <3 nM in HTRF assays, increases ZAP-70 phosphorylation in Jurkat cells with EC50 of 260 nM, does not inhibit LCK.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

CSK inhibitor 13 (SI-3, CSK-IN-1) is a potent, selective inhibitor of C-terminal Src kinase (CSK) with IC50 of <3 nM in HTRF assays, increases ZAP-70 phosphorylation in Jurkat cells with EC50 of 260 nM, does not inhibit LCK.
SI-3 inhibits recombinant LYN protein with a half-maximum inhibitory concentration (IC50) of 56.7 nM.
SI-3 induces LYN degradationm which is ubiquitin dependent.
CSK inhibitor 13 increases IL-2 secretion in CHO cells expressing OKT activate T cells proliferation.
CSK inhibitor 13 reduces inhibitory LCK phosphorylation in vivo upon oral dosing and shows the ability to enhance T cell activation in response to antigen stimulation.

CSK inhibitor 13 increases IL-2 secretion in CHO cells expressing OKT activate T cells proliferation.
CSK inhibitor 13 reduces inhibitory LCK phosphorylation in vivo upon oral dosing and shows the ability to enhance T cell activation in response to antigen stimulation.

物理化学性质&存储条件

分子量 671.13
分子式 C34H32ClFN8O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(3-chloro-4-(6-methoxypyrazolo[1,5-a]pyridine-3-carboxamido)phenyl)-1-(1-(3-cyano-3-methylbutanoyl)piperidin-4-yl)-5-fluoro-1H-indazole-3-carboxamide

参考文献

1. Daniel P O'Malley, et al. ACS Med Chem Lett. 2019 Sep 25;10(10):1486-1491.

2. Natalie S Scholes, et al. Nature. 2025 Nov 26. doi: 10.1038/s41586-025-09763-9.

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