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首页-小分子抑制剂&激动剂-JAK/STAT Signaling-Pim-CSH-4044
CSH-4044

Chemical Structure : CSH-4044

CAS No.:

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CSH-4044 (CSH4044)

货号: PC-25793Not For Human Use, Lab Use Only.

CSH-4044 is a specific, dual PIM and DYRK families of kinases inhibitor, reduces Tau phosphorylation at three residues, Tau S212, S202/T205 and T231, suppresses PIM3-driven BAD phosphorylation in pancreatic cancer cells and reduced DYRK1A-mediated Tau phosphorylation in neuronal cells.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

CSH-4044 is a specific, dual PIM and DYRK families of kinases inhibitor, reduces Tau phosphorylation at three residues, Tau S212, S202/T205 and T231, suppresses PIM3-driven BAD phosphorylation in pancreatic cancer cells and reduced DYRK1A-mediated Tau phosphorylation in neuronal cells.

物理化学性质&存储条件

分子量 347.34
分子式 C16H13NO6S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(2,5-dihydroxy-4-methoxyphenyl)(6-hydroxy-5-methoxybenzo[d]thiazol-2-yl)methanone

参考文献

1. Gyula Bencze, et al. bioRxiv [Preprint]. 2025 Oct 23:2025.10.22.683941.

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