CSF1R inhibitor 9

Chemical Structure : CSF1R inhibitor 9

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货号: PC-20762Not For Human Use, Lab Use Only.

CSF1R inhibitor 9 is a potent and highly selective purine-based inhibitor of CSF1R with enzymatic IC50 of 0.2 uM.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
200 mg		Get quote
1 g		Get quote

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生物&药学活性

CSF1R inhibitor 9 is a potent and highly selective purine-based inhibitor of CSF1R with enzymatic IC50 of 0.2 uM.
CSF1R inhibitor 9 shows excellent selectivity (Selectivity score: 0.06), evidenced by profiling towards a panel of 468 kinases.
CSF1R inhibitor 9 shows dose-dependent blockade of CSF1-mediated downstream signalling in murine bone marrow-derived macrophages (IC50=106 nM).
CSF1R inhibitor 9 (10 nM) inhibits p-ERK1/2 signalling, inhibits osteoclast differentiation.

物理化学性质&存储条件

分子量	367.45
分子式	C20H25N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	OCCC1=CC=C(C2=NC3=C(N(C)CC4CCOCC4)N=CN=C3N2)C=C1

参考文献

1. Thomas Ihle Aarhus, et al. Eur J Med Chem. 2023 Apr 28;255:115344.