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首页-小分子抑制剂&激动剂-Tyrosine Kinase-c-Fms (CSF1R)-CSF1R-IN-22
CSF1R-IN-22

Chemical Structure : CSF1R-IN-22

CAS No.: 2095849-04-8

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CSF1R-IN-22

货号: PC-62826Not For Human Use, Lab Use Only.

CSF1R-IN-22 is a potent, cellular active and orally bioavailable CSF1R inhibitor with IC50 of 0.5 nM, displays 120-fold selectivity over c-Kit.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    CSF1R-IN-22 is a potent, cellular active and orally bioavailable CSF1R inhibitor with IC50 of 0.5 nM, displays 120-fold selectivity over c-Kit.
    CSF1R-IN-22 has improved metabolic stability and Caco2 permeability.

    物理化学性质&存储条件

    分子量 479.463
    分子式 C25H20F3N5O2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    5-(1-methyl-1H-pyrazol-4-yl)-N-(2-methyl-5-(3-(trifluoromethyl)benzamido)phenyl)nicotinamide

    参考文献

    1. Ramachandran SA, et al. Bioorg Med Chem Lett. 2017 May 15;27(10):2153-2160.

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