CS27109 | THR-β agonist | Probechem Biochemicals

Chemical Structure : CS27109

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CS27109 (CS 27109)

货号: PC-20361Not For Human Use, Lab Use Only.

CS27109 is a potent, selective thyroid hormone receptor-β (THR-β) agonist with AC50 value of 1.98 uM, 12.6-fold selectivity over THR-α.

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生物&药学活性

CS27109 is a potent, selective thyroid hormone receptor-β (THR-β) agonist with AC50 value of 1.98 uM, 12.6-fold selectivity over THR-α.
CS27109 is about 10-fold more potent to activate THR-β than MGL3196 (Cat. PC-42920).
CS27109 (15 mg/kg) lessens liver steatosis in HFD rat model, also dose-dependently reduces liver inflammation.
CS27109 (15 mg/kg) mitigates steatohepatitis and hepatic fibrosis in WD + CCL4 mouse model.

物理化学性质&存储条件

分子量	532.11
分子式	C18H8Br2N6O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(3,5-dibromo-4-((4-oxo-3,4-dihydrophthalazin-1-yl)oxy)phenyl)-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile

参考文献

1. Shengjian Huang, et al. Int J Endocrinol. 2023 Feb 14;2023:4950597.

CS27109 (CS 27109)

生物&药学活性

物理化学性质&存储条件

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CS27109 (CS 27109)

生物&药学活性

物理化学性质&存储条件

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