CS12192 | JAK//TBK1 inhibitor | Probechem Biochemicals

Chemical Structure : CS12192

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CS12192 (CS 12192)

货号: PC-22634Not For Human Use, Lab Use Only.

CS12192 is a potent, selective JAK3/JAK1/TBK1 inhibitor with IC50 of 11/105/162 nM, respectively.

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生物&药学活性

CS12192 is a potent, selective JAK3/JAK1/TBK1 inhibitor with IC50 of 11/105/162 nM, respectively.
CS12192 inhibits Flt4 with IC50 of 107 nM, weakly inhibits JAK2 with an IC50 of 1404 nM.
CS12192 shows slightly over 50% of inhibitory activity only to a few other kinases (such as BMX, FLT3, KDR, but not TYK2) in an activity screening assay for a panel of 75 human kinases.
CS12192 inhibits IL-2 stimulation induced a clear phosphorylation of STAT1, 3, and 5 in KHYG-1 cell line.
CS12192 is a selective inhibitor against JAK3/JAK1, but not JAK2.
CS12192 suppresses IFN gene expression through the inhibition of TBK1 signaling pathway.
CS12192 (80 mg/kg) ameliorates disease severity of both AIA and CIA in rats.

物理化学性质&存储条件

分子量	507.95
分子式	C25H23ClFN7O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3-((5-chloro-2-((4-fluoro-3-(N-methylacrylamido)phenyl)amino)pyrimidin-4-yl)amino)propyl)-4-cyanobenzamide

参考文献

1. Shan S, et al. Int Immunopharmacol. 2019 Dec;77:105914.

CS12192 (CS 12192)

生物&药学活性

物理化学性质&存储条件

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CS12192 (CS 12192)

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物理化学性质&存储条件

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