CS-526 |CAS:313272-12-7 Probechem Biochemicals

Chemical Structure : CS-526

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CS-526 (AKU 517;R 105266)

货号: PC-62893Not For Human Use, Lab Use Only.

CS-526 (AKU 517.

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100 mg		Get quote
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500 mg		Get quote
1 g		Get quote

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生物&药学活性

CS-526 (AKU 517;R 105266) is a potent, competitive, and reversible acid pump antagonist (potassium-competitive acid blocker) that inhibits H+,K+-ATPase activity with IC50 of 61 nM; inhibits gastric acid secretion in pylorus-ligated rats with ID50 of 0.7 mg/kg (p.o.); inhibits histamine-stimulated gastric acid secretion in Heidenhain pouch dogs, inhibits acute gastric mucosal lesions and has potent antisecretory and antiulcer effects.

Ulcer

Phase 1 Discontinued

物理化学性质&存储条件

分子量	339.414
分子式	C20H22FN3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7-(4-fluorobenzyloxy)-2,3-dimethyl-1-{[(1S,2S)-2-methyl cyclopropyl]methyl}-1H-pyrrolo[2,3-d]pyridazine

参考文献

1. Ito K, et al. J Pharmacol Exp Ther. 2007 Oct;323(1):308-17.

2. Ito K, et al. J Pharmacol Exp Ther. 2008 Jul;326(1):163-70.

4. Ito K, et al. Biol Pharm Bull. 2009 Dec;32(12):2010-7.

CS-526 (AKU 517;R 105266)

生物&药学活性

物理化学性质&存储条件

参考文献

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CS-526 (AKU 517;R 105266)

生物&药学活性

物理化学性质&存储条件

参考文献

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