CRT0273750 (IOA-289)| Autotaxin inhibitor | Probechem Biochemicals

Chemical Structure : CRT0273750

CAS No.: 1979939-16-6

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CRT0273750 (CRT750, IOA-289)

货号: PC-38008Not For Human Use, Lab Use Only.

CRT0273750 (IOA-289) is a potent, seletive inhibitor of autotaxin with IC50 of 1 nM.

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5 mg	￥980	In stock
10 mg	￥1480	In stock
25 mg	￥2580	In stock
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100 mg		Get quote

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生物&药学活性

CRT0273750 (IOA-289) is a potent, seletive inhibitor of autotaxin with IC50 of 1 nM.
CRT0273750 (IOA-289) does not bind to the catalytic zinc region of ATX but binds to both the substrate pocket as well as to the LPA carrier channel thereby blocking both functions of ATX.
CRT0273750 modulates LPA levels in plasma and is suitable for in vivo studies.

物理化学性质&存储条件

分子量	502.922
分子式	C25H22ClF3N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-N-(1-(4-chlorophenyl)ethyl)-3-(3-(4-(trifluoromethoxy)benzyl)-3H-imidazo[4,5-b]pyridin-2-yl)propanamide

参考文献

1. Pritom Shah, et al. Bioorg Med Chem Lett. 2016 Nov 15;26(22):5403-5410.

CRT0273750 (CRT750, IOA-289)

生物&药学活性

物理化学性质&存储条件

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CRT0273750 (CRT750, IOA-289)

生物&药学活性

物理化学性质&存储条件

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