CRT0066854 | aPKC inhibitor | Probechem Biochemicals

Chemical Structure : CRT0066854

CAS No.: 1438881-19-6

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CRT0066854 (CRT 0066854)

货号: PC-20701Not For Human Use, Lab Use Only.

CRT0066854 is a potent and selective chemical inhibitor of atypical PKC (protein kinase C) isoforms PKCζ and PKCι with IC50 of 639 nM and 132 nM, respectively.

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5 mg	￥1380	In stock
10 mg	￥2180	In stock
25 mg	￥3780	In stock
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100 mg		Get quote

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生物&药学活性

CRT0066854 is a potent and selective chemical inhibitor of atypical PKC (protein kinase C) isoforms PKCζ and PKCι with IC50 of 639 nM and 132 nM, respectively.
CRT0066854 shows little to no acitvity agianst nPKCϵ (IC50=7.21 uM).
CRT0066854 is approximately 20-fold more potent for PKCζk and over 60-fold more potent for PKCιk than BIM-1.
CRT0066854 is a potent and selective chemical tool to modulate aPKC activity both in vitro and in cells, with no effect on PKCα or PKCϵ.
CRT0066854 inhibits the LLGL2 (lethal giant larvae 2) phosphorylation in HEK-293 cells (IC50=0.87 uM) and exhibits IC50 of 3.47 uM for A549 lung carcinoma cell viability.
CRT0066854 (3-12 uM) impedes directed migration of NRK cells.

物理化学性质&存储条件

分子量	415.56
分子式	C24H25N5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-3-phenyl-N1-(2-(pyridin-4-yl)-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-yl)propane-1,2-diamine

参考文献

1. Kjær S, et al. Biochem J. 2013 Apr 15;451(2):329-42.

2. Linch M, et al. Carcinogenesis. 2014 Feb;35(2):396-406.

CRT0066854 (CRT 0066854)

生物&药学活性

物理化学性质&存储条件

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CRT0066854 (CRT 0066854)

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物理化学性质&存储条件

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