CRT0066101

Chemical Structure : CRT0066101

CAS No.: 956123-34-5

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货号: PC-24285Not For Human Use, Lab Use Only.

CRT0066101 is a potent, specific, orally active pan-PKD (protein kinase D) inhibitor with biochemical IC50 of 1, 2.5 and 2 nM for PKD1, 2, and 3 respectively.

规格	价格	库存
5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥1980	In stock
50 mg	￥3480	In stock
100 mg		Get quote

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生物&药学活性

CRT0066101 is a potent, specific, orally active pan-PKD (protein kinase D) inhibitor with biochemical IC50 of 1, 2.5 and 2 nM for PKD1, 2, and 3 respectively.
CRT0066101 shows selectivity against a panel of > 90 protein kinases including PKCα/PKBα/MEK/ERK/c-Raf/c-Src/c-Abl.
CRT0066101 reduces bromodeoxyuridine incorporation, increases apoptosis, blocks neurotensin-induced PKD1/2 activation and reduces neurotensin-induced, PKD-mediated Hsp27 phosphorylation, attenuated PKD1-mediated NF-kappaB activation in pancreatic cancer cells.
CRT0066101 potently blocks tumor growth in vivo.

物理化学性质&存储条件

分子量	338.42
分子式	C18H22N6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-2-(4-((2-Aminobutyl)amino)pyrimidin-2-yl)-4-(1-methyl-1H-pyrazol-4-yl)phenol

参考文献

1. Harikumar KB, et al. Mol Cancer Ther. 2010 May;9(5):1136-46.

2. Coughlan KA, et al. J Biol Chem. 2016 Mar 11;291(11):5664-75.

3. Borges S, et al. Mol Cancer Ther. 2015 Jun;14(6):1306-16.

CRT0066101

生物&药学活性

物理化学性质&存储条件

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CRT0066101

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物理化学性质&存储条件

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