CREB inhibitor 666-15

Chemical Structure : CREB inhibitor 666-15

CAS No.: 1433286-70-4

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货号: PC-38619Not For Human Use, Lab Use Only.

CREB inhibitor 666-15 is a potent and selective inhibitor of CREB-mediated gene transcription with IC50 of 81 nM, potently inhibits cancer cell growth without harming normal cells.

规格	价格	库存
10 mg	￥1580	In stock
25 mg	￥2580	In stock
50 mg	￥3980	In stock
100 mg	￥5980	In stock
250 mg		Get quote

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生物&药学活性

CREB inhibitor 666-15 is a potent and selective inhibitor of CREB-mediated gene transcription with IC50 of 81 nM, potently inhibits cancer cell growth without harming normal cells.
CREB inhibitor 666-15 is highly seletive, shows very weak activity against NF-κB-mediated gene transcription with IC50 of >5 uM.
CREB inhibitor 666-15 decreases endogenous CREB target gene expression, shows significant inhibition of transcription of Nurr1/NR4A2 in HEK 293T cells at 50 nM.
CREB inhibitor 666-15 potently inhibits growth of MDA-MB-231 and MDA-MB-468 cells with GI50 in the midnanomolar concentration range (<100 nM).
CREB inhibitor 666-15 (10 mg/kg, i.p.) suppresses MDA-MB-468 tumor growth in vivo.

物理化学性质&存储条件

分子量	620.52
分子式	C33H31Cl2N3O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(3-Aminopropoxy)-N-[2-[[3-[[(4-chloro-2-hydroxyphenyl)amino]carbonyl]-2-naphthalenyl]oxy]ethyl]-2-naphthalenecarboxamide hydrochloride

参考文献

1. Fuchun Xie, et al. J Med Chem. 2015 Jun 25;58(12):5075-87.