CRE-14 | FABP4 inhibitor | Probechem Biochemicals

Chemical Structure : CRE-14

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CRE-14 (CRE14)

货号: PC-23932Not For Human Use, Lab Use Only.

CRE-14 is a specific, high affinity inhibitor of fatty acid-binding protein 4 (FABP4) with Kd of 654 nM in MST assays, impairs coronavirus replication.

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生物&药学活性

CRE-14 is a specific, high affinity inhibitor of fatty acid-binding protein 4 (FABP4) with Kd of 654 nM in MST assays, impairs coronavirus replication.
CRE-14 blocks FABP4's ability to bind its lipid ligand (BODIPY FL C12) in TR-FRET assays.
CRE-14 reduces SARS-CoV-2 virus nucleocapsid protein levels, reduces virus titers and disrupts replication organelles formation in adipocytes.
CRE-14 (5-10 uM) reduces viral titers across various SARS-CoV-2 variants in HBE cells.
CRE-14 (15 mg/kg, s.c.) significantly ameliorated the infection-associated weight loss and reduced lung viral titers in infected hamsters.

物理化学性质&存储条件

分子量	376.50
分子式	C24H28N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(6-hexyl-4-phenylquinolin-2-yl)-N-methylglycine

参考文献

1. Baazim H, et al. EMBO Mol Med. 2025 Jan 22. doi: 10.1038/s44321-024-00188-x.

2. Koyuncu E, Kim H, Hotamisligil G (2023) Novel cell metabolism modulating compounds and uses thereof for the treatment of viral diseases - US Patent Application 17/566692, Pub. No.: US20230210837A1

CRE-14 (CRE14)

生物&药学活性

物理化学性质&存储条件

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CRE-14 (CRE14)

生物&药学活性

物理化学性质&存储条件

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