CRAC inhibitor 36

Chemical Structure : CRAC inhibitor 36

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货号: PC-38654Not For Human Use, Lab Use Only.

CRAC inhibitor 36 is a novel potent, selective calcium release-activated calcium (CRAC) channels inhibitor with IC50 of 11 nM (IL-2 inhibition) and 243 nM (SOCE inhibition).

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

CRAC inhibitor 36 is a novel potent, selective calcium release-activated calcium (CRAC) channels inhibitor with IC50 of 11 nM (IL-2 inhibition) and 243 nM (SOCE inhibition).
CRAC inhibitor 36 showed decent potency and selectivity and a remarkable pharmacokinetic profile, good target engagement as measured by levels of IL-2 and TNF-α.

物理化学性质&存储条件

分子量	421.404
分子式	C23H17F2N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2,6-difluoro-N-(2'-methyl-3'-(4-methyl-5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)-[1,1'-biphenyl]-4-yl)benzamide

参考文献

1. Khedkar NR, et al. J Med Chem. 2021 Dec 9;64(23):17004-17030.