CR4056 |CAS:1004997-71-0 Probechem Biochemicals

Chemical Structure : CR4056

CAS No.: 1004997-71-0

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CR4056 (CR 4056, CR-4056)

货号: PC-35650Not For Human Use, Lab Use Only.

CR4056 (CR 4056, CR-4056) is a novel, orally active imidazoline-2 receptor (I2R) ligand/agonist with binding IC50 of 596 nM, also selectively inhibits the enzymatic activity of MAO-A with IC50 of 202.7 nM.

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5 mg	￥2580	In stock
10 mg	￥3980	In stock
25 mg	￥5980	In stock
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100 mg		Get quote

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生物&药学活性

CR4056 (CR 4056, CR-4056) is a novel, orally active imidazoline-2 receptor (I2R) ligand/agonist with binding IC50 of 596 nM, also selectively inhibits the enzymatic activity of MAO-A with IC50 of 202.7 nM.
CR4056 increases norepinephrine (NE) tissue levels both in the rat cerebral cortex and lumbar spinal cord, shows ED50 of 5.8 mg/kg in CFA rat model of inflammatory pain.
CR4056 shows high effectivity against bortezomib-induced painful neuropathy in rats.

物理化学性质&存储条件

分子量	272.311
分子式	C17H12N4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-(1H-imidazol-1-yl)-2-phenylquinazoline

参考文献

1. Ferrari F, et al. J Pain Res. 2011;4:111-25.

2. Thorn DA, et al. Br J Pharmacol. 2012 Jul;166(6):1936-45.

3. Meregalli C, et al. J Pain Res. 2012;5:151-67.

4. Lanza M, et al. Br J Pharmacol. 2014 Aug;171(15):3693-701.

CR4056 (CR 4056, CR-4056)

生物&药学活性

物理化学性质&存储条件

参考文献

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CR4056 (CR 4056, CR-4056)

生物&药学活性

物理化学性质&存储条件

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