CQ80 | PEPD/XPNPEP1 inhibitor | Probechem Biochemicals

Chemical Structure : CQ80

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CQ80 (CARD8 activator CQ80)

货号: PC-23105Not For Human Use, Lab Use Only.

CQ80 is a dual inhibitor of the Xaa-Pro-cleaving M24B aminopeptidases PEPD and XPNPEP1 with IC50 of 0.91 and 43 uM respectively, selectively activates the CARD8 inflammasome.

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生物&药学活性

CQ80 is a dual inhibitor of the Xaa-Pro-cleaving M24B aminopeptidases PEPD and XPNPEP1 with IC50 of 0.91 and 43 uM respectively, selectively activates the CARD8 inflammasome.
CQ80 induces CASP1-dependent cell death in MV4;11 cells with IC50s of 0.27 and 0.45 μM, respectively.
CQ80 is more effective inflammasome activator than CQ31. CQ80 activates the CARD8 inflammasome in both cancer cell lines and normal primary cells.
CQ80 does not activate the human or rodent NLRP1 inflammasomes.
CQ80 disrupts the CARD8-DPP9 ternary complex.

物理化学性质&存储条件

分子量	385.51
分子式	C19H35N3O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	methyl ((2S,3R)-3-amino-2-hydroxy-5-methylhexanoyl)-L-prolyl-L-leucinate

参考文献

1. Qifeng Chen, et al. J Med Chem. 2023 Feb 23;66(4):2589-2607.

CQ80 (CARD8 activator CQ80)

生物&药学活性

物理化学性质&存储条件

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CQ80 (CARD8 activator CQ80)

生物&药学活性

物理化学性质&存储条件

参考文献

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