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首页-小分子抑制剂&激动剂-Others-Other Targets-CQ211
CQ211

Chemical Structure : CQ211

CAS No.: 2648986-65-4

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CQ211 (CQ-211)

货号: PC-38737Not For Human Use, Lab Use Only.

CQ211 is a potent, highly selective RIOK2 (Right open reading frame kinase 2) inhibitor with Kd of 6.1 nM, shows excellent selectivity to RIOK2 in both enzymatic and cellular assays.

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5 mg ￥2980 In stock
10 mg ￥4880 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

CQ211 is a potent, highly selective RIOK2 (Right open reading frame kinase 2) inhibitor with Kd of 6.1 nM, shows excellent selectivity to RIOK2 in both enzymatic and cellular assays.
CQ211 exhibits potent proliferation inhibition activity against multiple cancer cell lines (HT20, cell IC50=0.38 uM) and demonstrates promising in vivo efficacy in mouse xenograft models.

物理化学性质&存储条件

分子量 521.504
分子式 C26H22F3N7O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

8-(6-Methoxypyridin-3-yl)-1-(4-(piperazin-1-yl)-3-(trifluoromethyl)phenyl)-1,5-dihydro-4H-[1,2,3]triazolo[4,5-c]quinolin-4-on

参考文献

1. Yifan Ouyang, et al. J Med Chem. May 18, 2022.

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