CPUY192018 | Keap1-Nrf2 inhibitor | Probechem Biochemicals

Chemical Structure : CPUY192018

CAS No.: 1803551-21-4

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CPUY192018 (CPUY-192018)

货号: PC-28127Not For Human Use, Lab Use Only.

CPUY192018 is a potent small-molecule inhibitor of the Keap1-Nrf2 PPI, has binding affinity for Keap1 with IC50 of 14.4 nM in FP assays and ITC Kd of 39.8 nM.

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10 mg	￥1480	In stock
25 mg	￥2580	In stock
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生物&药学活性

CPUY192018 is a potent small-molecule inhibitor of the Keap1-Nrf2 PPI, has binding affinity for Keap1 with IC50 of 14.4 nM in FP assays and ITC Kd of 39.8 nM.
CPUY192018 activated the Nrf2-ARE pathway in vitro.
CPUY192018 stimulated the transcription of the Nrf2-ARE regulated cytoprotective genes in NCM460 cells in an Nrf2-dependent manner.
CPUY192018 produced cytoprotective effects against the DSS-induced injury in the NCM460 cells.
CPUY192018 (40 mg/kg/day, oral gavage) ameliorated the pathological symptoms in the DSS-induced mouse model of chronic ulcerative colitis.

物理化学性质&存储条件

分子量	668.69
分子式	C30H28N4O10S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2,2'-(naphthalene-1,4-diylbis(((4-acetamidophenyl)sulfonyl)azanediyl))diacetic acid

参考文献

1. Lu MC, et al. Sci Rep. 2016 May 24;6:26585.

2. Jiang Z. Y. et al. J. Med. Chem. 58, 6410–6421,

CPUY192018 (CPUY-192018)

生物&药学活性

物理化学性质&存储条件

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CPUY192018 (CPUY-192018)

生物&药学活性

物理化学性质&存储条件

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